The ailments and function of blood disorders are based in historical evidence, but their effects on Bloodline descendants may vary somewhat from those of non-descendants.
These are scientifically advanced mechanical/electrical attachments grafted onto patients. Bloodline descendants tend to have a higher likelihood of surviving these procedures, because the enhancements usually interact with their blood disorder abilities.
“SAI” are created when uniquely powerful Bloodline descendants use items in meaningful/impactful ways in conjunction with their blood disorder abilities, thus imparting certain effects on the items. Wielders’ Chakra may also have effects on the items.